Molecular Mechanisms of the Circadian Clock and Its Role in Cell Cycle and Cancer
This community investigates the molecular machinery of the circadian clock, specifically how clock genes and proteins like BMAL1 regulate cell proliferation, cell cycle progression, and cancer development.
The research focuses on the interplay between circadian rhythms and cellular processes, with a strong emphasis on the suprachiasmatic nucleus and peripheral clocks. Recurring themes include the regulation of gene expression, cell proliferation, and the impact of clock dysfunction on cancer cells, particularly in contexts like hepatocellular carcinoma and glioblastoma. The work frequently employs systems biology approaches, mathematical modeling, and reaction network analysis to understand how these temporal regulators control fundamental biological processes.
The community’s output is distributed across various elements, with the largest shares found in oxygen, calcium, and carbon research, though these represent a small fraction of the total research for each element.
The community comprises 2,037 papers, with the highest publication volume in Cell, bioRxiv, and Cell Reports.
Recent work continues to explore the crosstalk between the circadian clock and stem cell niches, as well as the role of the intestinal clock in metabolic homeostasis and sleep-wake cycles.