Iron Metabolism, Ferroptosis, and Anemia Management
This community investigates how the body regulates iron levels and how iron-driven cell death, known as ferroptosis, influences disease processes. The work spans clinical management of iron deficiency and overload, as well as the molecular mechanisms controlling lipid peroxidation and cell survival.
The research focuses heavily on iron homeostasis, deficiency anemia, and the therapeutic application of intravenous and oral iron supplements. A significant portion of the work examines ferroptosis as a mechanism of cell death in cancer, heart failure, and kidney disease. Recurring themes include oxidative stress, lipid peroxidation, and the role of iron-sulfur clusters in cellular metabolism. Specific applications include treating anemia in pregnant women, managing iron overload in Friedreich’s ataxia, and developing strategies to target ferroptosis in breast, lung, and colorectal cancers. The community also explores the intersection of iron metabolism with immune cell function and tumor microenvironment dynamics.
The largest share of the community's output is found in iron research, accounting for 4.6% of all iron-related papers, with 17,296 papers in this group. Oxygen and sulfur research also contribute significantly, representing 0.4% and 0.5% of their respective element research totals.
The community comprises 24,427 papers, with the most frequent venues being Blood, the Journal of Biological Chemistry, and The Journal of Nutrition.
Recent work continues to explore the therapeutic targeting of ferroptosis in glioblastoma and melanoma, as well as the role of iron transfer in bone metastasis. Newer studies also examine iron delivery platforms for food fortification and the crosstalk between cell death pathways and immune responses in cancer.