Plasmonic Nanoparticles for Surface-Enhanced Raman Spectroscopy and Point-of-Care Diagnostics
This research community develops gold and silver nanostructures to amplify Raman signals and enable rapid, sensitive detection of biological and chemical targets in lateral flow assays and biosensors.
The work centers on the synthesis and characterization of gold nanoparticles, gold nanorods, and silver nanoparticles, often in core-shell or alloy configurations. These materials serve as substrates for surface-enhanced Raman spectroscopy (SERS), a technique that boosts weak molecular signals for identification. Recurring themes include the design of SERS substrates with controlled plasmonic resonance, the integration of these sensors into lateral flow immunoassays, and the application of colorimetric and electrochemical readouts. The research also frequently involves machine learning algorithms to process spectral data and improve detection accuracy for specific analytes, ranging from DNA sequences to disease biomarkers.
The largest share of the community's output is found in gold research, accounting for 10.7% of all gold-related papers, with 21,724 papers in this group. Silver research follows, representing 5.9% of silver-related papers with 10,527 entries.
The community comprises 47,735 papers, publishing most frequently in Langmuir, The Journal of Physical Chemistry C, and Journal of Raman Spectroscopy.
Recent work continues to focus on optimizing SERS substrates for biosensing, including dual-tunable hybrid arrays and multiwavelength Au@Ag nanoparticles. Other recent studies explore intelligent lateral flow assays with multi-metallic nanomaterials and the integration of surface-enhanced Raman spectroscopy with artificial intelligence and microfluidic technologies for biomedical applications.