Palladium- and Nickel-Catalyzed Carbonylation of Aryl and Alkyl Halides
This community develops catalytic methods that use carbon monoxide to build carboxylic acids, amides, and esters from aryl and alkyl halides, primarily using palladium and nickel catalysts.
The work focuses on carbonylative cross-coupling reactions, including Suzuki, Sonogashira, and aminocarbonylation variants. Recurring substrates include aryl iodides, arylboronic acids, and alkyl halides, while common products are carboxylic acids, amides, and cyclic derivatives. The research emphasizes the development of efficient, direct synthesis routes and the application of light-driven or single-electron-transfer mechanisms to activate these transformations. Specific attention is paid to the construction of complex molecular architectures through cyclization and the use of carbon monoxide as a C1 building block in total synthesis.
The community is most heavily represented in palladium research, accounting for 2.7% of all palladium-related papers tracked, with 2,686 papers in this group. It also contributes to carbon research, comprising 0.1% of that element's output with 1,082 papers.
There are 5,205 papers in this community, published primarily in The Journal of Organic Chemistry, Tetrahedron Letters, and Organic Letters.
Recent work continues to explore asymmetric carbonylation of alkynes, cobalt-catalyzed alkene carbonylation under electro-thermo-catalysis, and photoinduced copper-catalyzed carbonylation of arylthianthrenium salts.