Nanoparticle-Mediated Cancer Therapy and Targeted Drug Delivery
This research community focuses on the design and application of nanoscale materials, primarily gold and lipid-based nanoparticles, to deliver drugs and therapeutic agents directly to cancer cells. The work aims to improve treatment efficacy and reduce side effects in oncology and related diseases.
The core of this body of work involves the synthesis of gold nanoparticles, nanorods, and lipid nanoparticles for use in photothermal therapy, photoacoustic imaging, and targeted drug delivery. Recurring applications include the treatment of breast, lung, and colorectal cancers, as well as the delivery of gene therapies and extracellular vesicles. The research frequently employs Monte Carlo simulations to model radiation therapy and proton therapy interactions, while also exploring the use of mesenchymal stem cells and oxide nanoparticles. The primary goal is to create multifunctional platforms that combine diagnostic imaging with therapeutic intervention, often targeting specific tumor microenvironments to enhance the precision of cancer treatment.
The largest share of the community's output is found in gold research, representing 8.2% of all gold-related papers tracked, with 15,174 papers in this group. Silver and platinum research also contribute significantly, accounting for 0.6% and 0.7% of their respective element research, with 1,022 and 971 papers here.
The community comprises 45,851 papers, with the most frequent publications appearing in the International Journal of Nanomedicine, Pharmaceutics, and Langmuir.
Recent work continues to focus on clinical translation strategies for nanoparticle-based drug delivery, including advancements in brain-targeted delivery for neurodegenerative diseases and AI-driven nanomedicine for cancer theranostics.