Singlet Oxygen Generation, Detection and Photodynamic Applications
This community investigates the creation, behavior, and measurement of singlet oxygen, an excited form of molecular oxygen, and applies these processes to photodynamic therapy, proximity labeling in biological systems, and the oxidation of organic molecules.
The work centers on the synthesis and characterization of photosensitizers, such as porphyrins and chlorophyllins, that generate singlet oxygen upon light exposure. Key activities include measuring quantum yields, studying oxygen quenching mechanisms, and developing methods for detecting singlet oxygen luminescence. Applications span the photodynamic inactivation of bacteria like Staphylococcus aureus, the use of proximity labeling to map protein interactions and cell surface neighbors, and the oxidative stability of emulsions and food products. The research also explores the role of singlet oxygen in photosensitization reactions of biomolecules and the development of photocatalytic systems for selective oxidation.
The largest share of the community's output is found in oxygen research, accounting for 2.5% of all tracked oxygen research, with 3,669 papers in this group.
The community comprises 7,237 papers, publishing primarily in Photochemistry and Photobiology, the Journal of the American Chemical Society, and Tetrahedron Letters.
Recent work focuses on photocatalytic proximity labeling for mapping protein binding sites and cell surface interactions, the use of laser-generated singlet oxygen in neuroprotection studies, and the development of halogen-regulated photosensitizers for water purification.