Manganese Exposure, Neurotoxicity and Oxidative Stress Mechanisms
This community investigates how manganese exposure affects human health, focusing on neurodegenerative conditions, oxidative stress pathways, and the biological mechanisms of manganese homeostasis.
The research centers on the toxicological impact of manganese, particularly through occupational sources like welding fumes and environmental sources such as drinking water. Recurring themes include the assessment of blood manganese levels, the induction of oxidative stress, and the development of neurodegenerative disorders such as Parkinson’s disease and amyotrophic lateral sclerosis. The work frequently employs animal models, specifically rats and mice, to study signaling pathways and cellular responses to manganese-induced injury. Additionally, the community examines the role of manganese in trace element nutrition, including its transport mechanisms and the health risks associated with both deficiency and excess in various populations.
Manganese is the dominant element in this group, accounting for 5,085 papers, which represents 3.8% of all manganese research tracked. Iron and Zinc follow with 726 and 498 papers respectively, each contributing 0.2% of their respective element research.
The community comprises 8,106 papers, with the highest publication volumes in NeuroToxicology, Biological Trace Element Research, and Environmental Research.
Recent work continues to focus on the molecular mechanisms of manganese transport, such as the SLC30A10-mediated pathway, and the link between manganese-induced neuroinflammation and mitochondrial dysfunction. Studies also examine the diagnostic criteria for amyotrophic lateral sclerosis and the health risks associated with welding fume exposure.