Surface Plasmon Resonance Sensors for Biosensing and Refractive Index Detection

This community designs optical sensors that use surface plasmon resonance to detect biological molecules, cancer biomarkers, and changes in refractive index.

The work centers on integrating plasmonic materials with optical fiber structures, particularly photonic crystal fibers, to create highly sensitive detection platforms. Recurring methods include the use of gold nanoparticles, graphene oxide, and black phosphorus to enhance signal sensitivity. Applications are predominantly biomedical, focusing on cancer cell detection, biosensor development, and the identification of specific analytes like tyramine and aflatoxin. The research also explores machine learning techniques to optimize sensor design and improve detection accuracy for complex biological targets.

The community is most prominent in research involving gold, where it accounts for 0.5% of all gold-related papers, and in indium research, representing 0.3% of that element's output. It also contributes 0.4% of tin research.

The community comprises 2,248 papers, published primarily in Plasmonics, Optics & Laser Technology, and Optical Fiber Technology.

Recent work continues to focus on optimizing SPR biosensors for cancer biomarker detection and integrating machine learning for enhanced refractive index sensing and hemoglobin detection.

Papers behind this description

Advancements in optical fiber-based wearable sensors for smart health monitoring — Biosensors and Bioelectronics, 2024 — doi:10.1016/j.bios.2024.116232
Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications—A Comprehensive Review — Biosensors, 2025 — doi:10.3390/bios15010035
WaveFlex Biosensor: MXene-Immobilized W-shaped Fiber-Based LSPR sensor for highly selective tyramine detection — Optics & Laser Technology, 2024 — doi:10.1016/j.optlastec.2023.110357
Recent Advances in Photonic Crystal Fiber-Based SPR Biosensors: Design Strategies, Plasmonic Materials, and Applications — Micromachines, 2025 — doi:10.3390/mi16070747
Surface Plasmon Resonance (SPR) Sensor for Cancer Biomarker Detection — Biosensors, 2023 — doi:10.3390/bios13030396
Numerical Study of a Novel Kagome-Inspired Photonic Crystal Fiber-Based Surface Plasmon Resonance Biosensor for Detection of Blood Components and Analytical Targets — Biosensors, 2025 — doi:10.3390/bios15080539
Finite Element Method-Based Modeling of a Novel Square Photonic Crystal Fiber Surface Plasmon Resonance Sensor with a Au–TiO2 Interface and the Relevance of Artificial Intelligence Techniques in Sensor Optimization — Photonics, 2025 — doi:10.3390/photonics12060565
Advancements and Perspectives in Optical Biosensors — ACS Omega, 2024 — doi:10.1021/acsomega.4c01872
WaveFlex Biosensor-Using Novel Tri-Tapered-in-Tapered Four-Core Fiber With Multimode Fiber Coupling for Detection of Aflatoxin B1 — Journal of Lightwave Technology, 2023 — doi:10.1109/jlt.2023.3301069
Highly sensitive cancer detection using an open D-channel PCF-based SPR biosensor — Scientific Reports, 2025 — doi:10.1038/s41598-025-95249-7
Ultra-sensitive surface plasmon resonance sensor integrating MXene (Ti3C2TX) and graphene for advanced carcinoembryonic antigen detection — Scientific Reports, 2025 — doi:10.1038/s41598-025-97853-z
Recent advances of optical fiber biosensors based on surface plasmon resonance: sensing principles, structures, and prospects — Sensors & Diagnostics, 2024 — doi:10.1039/d4sd00045e
A Tutorial Review on Surface Plasmon Resonance Biosensors: Applications in Biomedicine — ACS Bio & Med Chem Au, 2025 — doi:10.1021/acsbiomedchemau.5c00182
Design and optimization of a hybrid SPR biosensor for highly sensitive detection of carcinoembryonic antigen — Next Materials, 2025 — doi:10.1016/j.nxmate.2025.101526
Machine learning-enhanced SPR-based optical biosensor for cancer cell detection — Optics & Laser Technology, 2025 — doi:10.1016/j.optlastec.2025.113796
Next-generation COVID-19 detection using a metasurface biosensor with machine learning-enhanced refractive index sensing — Scientific Reports, 2025 — doi:10.1038/s41598-025-18753-w
Machine learning-enhanced high-sensitivity hemoglobin detection using a Kretschmann-based SPR biosensor with optimized copper and silver layers — Chemical Engineering Journal, 2025 — doi:10.1016/j.cej.2025.169485
Ultra-sensitive refractive index sensing enabled by high-Q hybrid plasmonic metasurface absorbers — Optics & Laser Technology, 2025 — doi:10.1016/j.optlastec.2025.113743