Copper, Nickel and Cobalt Coordination Chemistry and Enzyme Mimetics
This community focuses on the synthesis and structural characterization of transition metal complexes, primarily to model the active sites of metalloenzymes and develop inhibitors for copper-dependent enzymes like tyrosinase.
The research is dominated by the design of ligands for copper, nickel, and cobalt, with a heavy emphasis on crystallographic analysis and Hirshfeld surface studies. A significant portion of the work targets tyrosinase inhibitors, exploring how copper chelation affects enzyme kinetics. Additionally, the community investigates the mechanisms of lytic polysaccharide monooxygenases and electron transfer processes in binuclear copper systems. These studies bridge synthetic inorganic chemistry and biological function, often using molecular docking to predict interactions between metal complexes and biological targets.
The largest share of the community's output is found in cobalt research, accounting for 3.1% of all cobalt research, and 4,475 papers here. Copper research follows closely with 1.4% of its total research and 4,461 papers in this group.
The community comprises 16,643 papers, published primarily in Inorganic Chemistry, Inorganica Chimica Acta, and the Bulletin of the Chemical Society of Japan.
Recent work continues to explore copper-oxygen adducts for C-H bond activation and the design of specific copper-chelating tyrosinase inhibitors, such as thiosemicarbazones and boronic derivatives.