Hyperpolarized Gas and NMR Imaging for Chronic Lung Disease
This community develops advanced magnetic resonance techniques to visualize gas exchange and tissue function in patients with chronic obstructive pulmonary disease, asthma, and other obstructive lung conditions.
The work centers on the production and application of hyperpolarized noble gases, particularly xenon-129 and helium-3, for ventilation and perfusion imaging. Recurring methods include dynamic nuclear polarization, solid-state NMR spectroscopy, and reversible exchange techniques to enhance signal sensitivity. These imaging modalities are applied to assess lung function, detect small airway disease, and monitor treatment responses in patients with COPD and severe asthma. The research also encompasses the development of bromide-based compounds and the evaluation of bronchodilator therapies such as ipratropium and tiotropium.
The largest share of this community's output is found in xenon research, accounting for 3.9% of all xenon research, and 1,529 papers here. Bromine research follows with 1.2% of its total research and 1,243 papers.
The community comprises 12,918 papers, publishing primarily in Magnetic Resonance in Medicine, the European Respiratory Journal, and Thorax.
Recent work includes the 2026 update to the GOLD COPD report, studies on the role of neutrophils in COPD inflammation, and randomized trials of targeted lung denervation.