Nanoparticle-Based Drug Delivery and Targeted Cancer Therapy
This community focuses on the design and application of nanoscale materials, particularly gold and lipid-based particles, to transport drugs and genetic material to specific cells, primarily for the treatment of cancer and other diseases.
The research centers on the synthesis and functionalization of nanoparticles, with a heavy emphasis on gold nanoparticles, gold nanorods, and lipid nanoparticles. Key applications include targeted drug delivery systems, photothermal therapy, and gene therapy, often directed at specific cancer types such as breast, lung, and colorectal cancer. The work also extensively covers extracellular vesicles and stem cell-derived exosomes as natural delivery vehicles. A significant portion of the literature addresses the challenges of crossing the blood-brain barrier for neurological applications, as well as the characterization of the protein corona that forms around nanoparticles in biological fluids. Methods range from in vitro cell studies to in vivo animal models, with a strong focus on enhancing therapeutic efficacy while minimizing off-target effects.
The largest share of the community's output is found in gold research, accounting for 5.5% of all gold research tracked, with 11,131 papers in this group. This is the element with the highest paper count within this community.
The community comprises 37,187 papers, published most frequently in the International Journal of Nanomedicine, Pharmaceutics, and Journal of Nanobiotechnology.
Recent work continues to focus on clinical translation strategies for nanoparticle-based delivery, including advanced formulation methods for overcoming biological barriers. Specific recent studies address targeted delivery across the blood-brain barrier for Alzheimer's disease, the use of multifunctional gold nanoparticles for cancer theranostics, and the integration of artificial intelligence with nanodiagnostics for neurodegenerative diseases.