Hyperpolarized Gas MRI for Lung and Brain Function
This community develops and applies advanced magnetic resonance imaging techniques, specifically using hyperpolarized noble gases, to visualize and measure physiological function in the lungs and brain.
The research centers on the production and application of hyperpolarized gases, particularly xenon and helium, to image lung ventilation and oxygenation in conditions such as chronic obstructive pulmonary disease, cystic fibrosis, and pulmonary embolism. A parallel strand of work applies these techniques, along with near-infrared spectroscopy, to assess cerebral blood flow and oxygen saturation in patients with ischemic stroke, traumatic brain injury, and after cardiac arrest. The methodology relies heavily on dynamic nuclear polarization to enhance signal strength, enabling functional assessment rather than just anatomical imaging.
The largest share of the community's output is found in xenon research, accounting for 11.8% of all xenon research, and 3,479 papers here. Oxygen and helium research also contribute significantly, with 1,709 and 902 papers respectively.
The community comprises 26,445 papers, primarily published in Anesthesiology, Stroke, and the British Journal of Anaesthesia.
Recent work includes randomized controlled trials for targeted lung denervation in COPD, systematic reviews on postoperative delirium, and investigations into cerebral vascular disturbances following traumatic brain injury.