Cyclodextrin Inclusion Complexes for Drug Delivery and Functional Materials
This research community develops cyclodextrin-based inclusion complexes to improve the solubility, stability, and delivery of active compounds, with a strong focus on pharmaceutical applications and functional material design.
The work centers on the synthesis and characterization of cyclodextrins and their derivatives, particularly hydroxypropyl-β-cyclodextrin, to form host-guest inclusion complexes. Key applications include enhancing drug bioavailability, stabilizing essential oils, and improving the physicochemical properties of active ingredients. Methods frequently involve capillary electrophoresis, molecular dynamics simulations, and physicochemical thermal analysis to evaluate complexation efficiency and stability. While the primary focus is pharmaceutical formulation, the community also explores applications in food packaging, antioxidant activity, and supramolecular assembly for sensing and material science.
The community’s output is most heavily concentrated in research tracked for sodium, where it represents 0.1% of all sodium-related papers, and for bromine, where it accounts for 0.1% of bromine research. It also contributes significantly to hydrogen research, comprising 0.0% of that element's tracked literature.
The community comprises 2,991 papers, with the majority published in Pharmaceutics, International Journal of Pharmaceutics, and Carbohydrate Polymers.
Recent work continues to focus on cyclodextrin applications in advanced drug delivery systems, including nanoparticle-based oral insulin delivery and cyclodextrin-liposome formulations, as well as their use in cosmetic industry applications and the encapsulation of polyphenols.