Chromatography and Mass Spectrometry for Bioanalysis and Chemical Profiling
This community develops and validates analytical methods to separate, identify, and quantify complex mixtures of chemicals in biological fluids, pharmaceutical products, and natural extracts.
The work centers on coupling liquid and gas chromatography with tandem mass spectrometry to achieve high sensitivity and specificity. Recurring applications include the simultaneous determination of drug concentrations in human plasma and serum, the profiling of essential oil compositions, and the quantification of fatty acids and other biomarkers. Methods are frequently validated for use in dosage forms and forensic samples, with a strong emphasis on isotope dilution techniques to ensure accuracy. The research also addresses the chemical composition of plant-derived materials and the detection of specific compounds in food and environmental matrices.
The community’s output is most concentrated in research involving Bromine, where it represents 0.6% of all tracked work for that element, followed by Sodium at 0.3% and Nitrogen, Phosphorus, and Chlorine at 0.2% each. Nitrogen also contributes the highest absolute number of papers within this group, with 1,000 entries.
The community comprises 19,500 papers, published predominantly in the Journal of Chromatography A, the Journal of Chromatography B, and Analytical Chemistry.
Recent work includes the evaluation of chromatographic techniques for aroma profiling in kombucha, the determination of mineral oil hydrocarbons in food matrices, and the development of stationary phases for separating highly polar compounds.