Hydrogen Sulfide and Reactive Sulfur Species in Biological Sensing and Therapy
This community develops chemical tools to detect and manipulate hydrogen sulfide and related reactive sulfur species within living systems, primarily for medical diagnostics and therapeutic intervention.
The work centers on the design of fluorescent probes and sensors capable of selectively identifying hydrogen sulfide, sulfane sulfur, and other reactive sulfur species in complex biological environments. A significant portion of the research focuses on ratiometric and near-infrared fluorescent probes for imaging these molecules in living cells and tissues. The applications span monitoring oxidative stress, tracking signaling pathways, and supporting therapies for conditions such as cancer, wound healing, and cardiovascular injury. The community also investigates sulfur dioxide and nitric oxide as related gaseous signaling molecules, often developing multi-analyte detection platforms. These chemical tools are used to study the physiological roles of sulfur species in disease mechanisms and to evaluate the efficacy of sulfur-based therapeutic agents.
The largest share of the community's output is found in sulfur research, accounting for 9.5% of all sulfur research, and 3,038 papers here.
The community comprises 4,310 papers, publishing most frequently in Nitric Oxide, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, and Antioxidants and Redox Signaling.
Recent work continues to focus on the development of advanced fluorescent probes for real-time monitoring of hydrogen sulfide in specific biological contexts, including food freshness assessment and neurochemical signaling, as well as the use of sulfur-releasing materials for wound healing and cancer therapy.
Papers behind this description
- Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets — Signal Transduction and Targeted Therapy, 2024 — doi:10.1038/s41392-024-01811-6
- Nitric Oxide, Stress, and Depression — Psychopharmacology Bulletin, 2025 — doi:10.64719/pb.4268
- Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species — Chemical Reviews, 2024 — doi:10.1021/acs.chemrev.3c00683
- Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation — Redox Biology, 2024 — doi:10.1016/j.redox.2024.103066
- Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs — Physiological Reviews, 2022 — doi:10.1152/physrev.00028.2021
- Detection and analysis of chiral molecules as disease biomarkers — Nature Reviews Chemistry, 2023 — doi:10.1038/s41570-023-00476-z
- Near infrared fluorescent probes for detecting and imaging active small molecules — Coordination Chemistry Reviews, 2023 — doi:10.1016/j.ccr.2023.215080
- Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice — Nature Metabolism, 2024 — doi:10.1038/s42255-024-01068-x
- Engineered aggregation-induced emission luminogens-based framework with CO-releasing property for accelerating diabetic wound healing — Chemical Engineering Journal, 2025 — doi:10.1016/j.cej.2025.168981
- The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species — Pharmacology & Therapeutics, 2021 — doi:10.1016/j.pharmthera.2021.107916
- Reactive Sulfur Species and Protein Persulfidation: An Emerging Redox Axis in Human Health and Disease — Current Issues in Molecular Biology, 2025 — doi:10.3390/cimb47090765
- Hydrogen sulfide drives horizontal transfer of plasmid-borne antibiotic resistance genes in wastewater ecosystems — Nature Water, 2025 — doi:10.1038/s44221-025-00523-7
- Ultrasensitive Electrochemiluminescence Detection of Dual Tumor Markers on Living Cell Surface with a Closed Bipolar Electrode Array Chip — Analytical Chemistry, 2026 — doi:10.1021/acs.analchem.5c07917
- Hydrogen sulfide in cancer therapy: Intelligent delivery platforms and synergistic therapeutic paradigms — Advanced Drug Delivery Reviews, 2025 — doi:10.1016/j.addr.2025.115717
- Peptide-based AIE fluorescent probe for sequential detection of Hg2+ and S2− and its multi-functional applications — Journal of Molecular Structure, 2025 — doi:10.1016/j.molstruc.2025.144695
- Hydrogen Sulfide in Balneology: Physiology, Evidence, and Clinical Translation — International Journal of Molecular Sciences, 2025 — doi:10.3390/ijms262110790