Cyclodextrin Inclusion Complexes for Drug Delivery and Stability
This community investigates how cyclodextrins, a class of cyclic sugar molecules, form inclusion complexes with drugs, essential oils, and other active compounds to improve their solubility, stability, and delivery profiles in pharmaceutical and food applications.
The research focuses on the synthesis and characterization of cyclodextrin derivatives and their host-guest interactions with specific molecules like diclofenac sodium, rosuvastatin calcium, and essential oils. Key methods include the preparation of solid dispersions, dry powders, and nanosponges, followed by rigorous physicochemical evaluation of thermal stability, solubility, and bioavailability. The work frequently employs in vitro testing using cell lines and animal models such as Sprague Dawley rats to assess the efficacy of these delivery systems. Additionally, molecular dynamics simulations are used to understand the structural mechanics of these complexes, while capillary electrophoresis and other analytical techniques verify the formation and properties of the final formulations.
The community is most prominent in research tracked for sodium, where it represents 0.2% of all sodium-related papers, and magnesium, also at 0.2%. It contributes 437 papers to the sodium research base and 283 to the magnesium base, making sodium the element with the highest absolute paper count within this group.
The community comprises 3,553 papers, with the highest publication volume in the International Journal of Pharmaceutics, Pharmaceutics, and the Journal of Pharmaceutical Sciences.
Recent work continues to explore cyclodextrins as active therapeutic agents beyond their traditional role as excipients, alongside applications in encapsulating polyphenols for food preservation and developing supramolecular assemblies for advanced functional materials.