Indium-111 Radiolabeling for Cellular Imaging and Quantitative Analysis
This community focuses on the use of the radioactive isotope indium-111 to label blood cells and other biological materials for medical imaging and laboratory measurement. The work primarily addresses how to attach this isotope to platelets, white blood cells, and red blood cells to track their movement and accumulation in the human body, as well as the chemical methods used to detect and quantify indium and other metals in analytical chemistry.
The recurring subject matter is the application of indium-111 as a radiotracer. Papers describe labeling autologous granulocytes and platelets to diagnose inflammatory bowel disease, venous thrombosis, and respiratory infections. A parallel strand involves the chemical synthesis of organic reagents, such as 2-(2-thiazolylazo)-p-cresol, for the spectrophotometric determination of indium and other heavy metals. These methods are applied in nuclear medicine for scintigraphy and in analytical chemistry for precise metal quantification.
The community is overwhelmingly concentrated in indium research, accounting for 295 papers, which represents 0.8% of all tracked indium research. Bismuth and krypton contribute smaller numbers of papers, but indium remains the dominant element associated with this body of work.
The community comprises 339 papers, published most frequently in Analytica Chimica Acta, The British Journal of Radiology, and Circulation. The most recent work is not yet well covered in the available data.
Papers behind this description
- Editorial: Platelets and Immune Responses During Thromboinflammation — Frontiers in Immunology, 2020 — doi:10.3389/fimmu.2020.01079
- Reexamination of the chromium‐51–labeled posttransfusion red blood cell recovery method — Transfusion, 2019 — doi:10.1111/trf.15310
- Selective extraction-photometric determination of silver (i) with dithizone — E3S Web of Conferences, 2023 — doi:10.1051/e3sconf/202337101002
- Comparison of Two Preconcentration Methods for the Determination of Nickel Using a Ni–2-(2-thiazolylazo)-p-Cresol Complex: Extraction and Sorption onto Ion Exchange Resin — Journal of Analytical Chemistry, 2022 — doi:10.1134/s1061934822110132
- Red cell volume measurement – using indium as a replacement for chromium — Nuclear Medicine Communications, 2020 — doi:10.1097/mnm.0000000000001185
- Cadmium electrodeposition on copper substrate for cyclotron production of 111In radionuclide — Journal of Radioanalytical and Nuclear Chemistry, 2010 — doi:10.1007/s10967-010-0448-1
- Indium-111-octreotide Scintigraphy, Intraoperative Gamma-detector Localisation and Somatostatin Receptor Expression in Primary Human Breast Cancer — Breast Cancer Research and Treatment, 2002 — doi:10.1023/a:1016120529858
- 2-(2-Thiazolylazo)-p-cresol as a spectrophotometric reagent for vanadium determination in the presence of ascorbic acid — Mikrochimica Acta, 1998 — doi:10.1007/bf01246856
- Advances in the Synthesis of New Organic Reagents for the Determination of Noble and Heavy Metals — Journal of Analytical Chemistry, 2003 — doi:10.1023/a:1025624915259
- Indium 111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease — Gastroenterology, 1986 — doi:10.1016/0016-5085(86)90376-890376-8)
- A New Low‐Frequency Red Cell Antigen, ‘SARAH’ — Vox Sanguinis, 1994 — doi:10.1111/j.1423-0410.1994.tb05040.x
- Reduction in deposition of indium 111—labeled platelets after autologous endothelial cell seeding of Dacron aortic bifurcation grafts in humans: A preliminary report — Journal of Vascular Surgery, 1987 — doi:10.1067/mva.1987.avs0060017