Pulsed-Field Ablation for Atrial Fibrillation and Cardiac Arrhythmias
This community focuses on the development and clinical application of pulsed-field ablation, a non-thermal technique used to treat atrial fibrillation and other cardiac arrhythmias.
The work centers on the efficacy and safety of pulsed-field ablation compared to traditional thermal methods like radiofrequency and cryoballoon ablation. Recurring themes include pulmonary vein isolation, the management of paroxysmal and persistent atrial fibrillation, and the evaluation of irreversible electroporation mechanisms. A significant portion of the literature addresses specific safety concerns, particularly hemolysis and its potential impact on renal function, as well as the characterization of lesion formation in cardiac tissue. The community also examines the integration of these techniques with catheter mapping systems and their application in complex cases, including scar-related ventricular tachycardia and left atrial appendage occlusion.
The largest share of the community's output is found in calcium research, accounting for 0.0% of all calcium research, and 101 papers here.
The community comprises 2,536 papers, published primarily in Heart Rhythm, EP Europace, and the Journal of Cardiovascular Electrophysiology.
Recent work includes large multicenter safety studies involving tens of thousands of patients, head-to-head trials comparing pulsed-field ablation with radiofrequency and cryoballoon techniques, and investigations into the long-term outcomes of using this modality as initial therapy for persistent atrial fibrillation.