Photoredox and Transition-Metal Catalysis for C–C Bond Formation
This research community develops catalytic methods to form carbon-carbon bonds using light and transition metals, enabling the construction of complex organic molecules from simple starting materials.
The work centers on the integration of photoredox catalysis with transition-metal catalysis, particularly nickel, copper, and palladium. Recurring themes include cross-coupling reactions of unactivated alkenes, alkyl halides, and carboxylic acids, as well as the generation and manipulation of radical intermediates. Key methodologies involve hydrogen atom transfer, atom transfer radical addition, and dual catalytic systems that combine light-driven redox processes with metal-mediated bond formation. The output is frequently applied to stereoselective and enantioselective synthesis, including total synthesis of natural products and the creation of bioisosteres for medicinal chemistry.
The community is most prominent in research tracked for Nickel, representing 1.5% of all Nickel research, and Palladium, representing 2.0% of all Palladium research. It also constitutes a significant portion of Copper research, at 0.6%.
This research community comprises 24,530 papers, with the highest publication volume in the Journal of the American Chemical Society, Organic Letters, and Angewandte Chemie International Edition.
Recent work continues to focus on expanding the scope of photocatalytic reactions, including the development of ligand-to-metal charge transfer mechanisms, the synthesis of strained ring systems like bicyclo[1.1.0]butanes, and the application of these methods to generate diverse radical intermediates from boronic acids and other functional groups.