Transition-Metal Catalyzed Cross-Coupling and Asymmetric Synthesis
This community develops catalytic methods for forming carbon-carbon and carbon-heteroatom bonds, with a strong focus on creating chiral molecules for pharmaceuticals and fine chemicals.
The research centers on palladium, rhodium, and nickel-catalyzed reactions, particularly Suzuki-Miyaura cross-coupling and C-H bond activation. A significant portion of the work addresses enantioselective synthesis, using chiral ligands to produce single-enantiomer products. Recent efforts integrate photoredox catalysis and electrochemical methods to drive these transformations. The community also investigates hypervalent iodine reagents and fluorinated building blocks, reflecting the importance of these functional groups in medicinal chemistry.
The largest share of this community's output is found in palladium research, accounting for 52.0% of all palladium research tracked, with 14,943 papers in this group. Rhodium research also shows a high concentration, representing 37.7% of rhodium research with 3,858 papers. Fluorine research contributes 14.6% of its total output, comprising 4,492 papers.
The community comprises 57,485 papers, publishing primarily in the Journal of Fluorine Chemistry, Organic Letters, and the Journal of the American Chemical Society.
Recent work includes copper-catalyzed asymmetric cross-couplings, photocatalytic oxygen-atom transmutations, and the synthesis of heterobicycloalkanes. Other recent studies focus on transaminase-catalyzed asymmetric synthesis of active pharmaceutical ingredients and the use of boronic acids in radical generation.
Papers behind this description
- Recent Progress in Synthetic Applications of Hypervalent Iodine(III) Reagents — Chemical Reviews, 2024 — doi:10.1021/acs.chemrev.4c00303
- Direct Photocatalyzed Hydrogen Atom Transfer (HAT) for Aliphatic C–H Bonds Elaboration — Chemical Reviews, 2021 — doi:10.1021/acs.chemrev.1c00263
- P-Stereogenic Phosphorus Ligands in Asymmetric Catalysis — Chemical Reviews, 2024 — doi:10.1021/acs.chemrev.3c00875
- Photobiocatalytic Strategies for Organic Synthesis — Chemical Reviews, 2023 — doi:10.1021/acs.chemrev.2c00767
- Rhodium-Catalyzed Asymmetric C–H Functionalization Reactions — Chemical Reviews, 2023 — doi:10.1021/acs.chemrev.3c00149
- Enantioselective electrochemical cobalt-catalyzed aryl C–H activation reactions — Science, 2023 — doi:10.1126/science.adg2866
- Enantioselective [2π + 2σ] Cycloadditions of Bicyclo[1.1.0]butanes with Vinylazaarenes through Asymmetric Photoredox Catalysis — Journal of the American Chemical Society, 2024 — doi:10.1021/jacs.3c14077
- β-Acyloxyl alkenyl amide synthesis via multiple defluorination: α-Trifluoromethyl ketone–amine as synergystic peptide coupling reagent — Science Advances, 2025 — doi:10.1126/sciadv.aea4120
- Enantioselective Assembly of (Hetero)aryl Alkyl Sulfilimines via Copper-Catalyzed S -Arylation of S -Alkyl Sulfenamides with (Hetero)aryl Iodides — Journal of the American Chemical Society, 2025 — doi:10.1021/jacs.5c12689
- Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients — Green Synthesis and Catalysis, 2025 — doi:10.1016/j.gresc.2024.03.003
- Copper-catalysed asymmetric cross-coupling reactions tolerant of highly reactive radicals — Nature Chemistry, 2025 — doi:10.1038/s41557-025-01970-1