Nitric Oxide Signaling, Delivery, and Physiological Regulation
This community investigates the biological role of nitric oxide (NO) as a signaling molecule, the mechanisms that produce and transport it, and its impact on cardiovascular, respiratory, and muscular function.
The research focuses heavily on the synthesis of NO by nitric oxide synthase enzymes and its regulation in endothelial and immune cells. A significant portion of the work examines the "nitrate-nitrite-NO" pathway, where dietary nitrate and sodium nitrite serve as precursors for NO production, particularly in contexts of exercise physiology and blood pressure regulation. The community also explores chemical delivery systems, including ruthenium nitrosyl complexes and nitric oxide-releasing molecules, designed to control the release of NO for therapeutic purposes. Applications span the treatment of pulmonary hypertension and sickle cell disease, the study of oxidative stress, and the optimization of athletic performance through interval training and oxygen uptake analysis.
The largest share of the community's output is found in oxygen research, accounting for 1.0% of all oxygen research, and 5,282 papers here. Sodium research follows with a 0.6% share and 1,617 papers.
The community comprises 25,555 papers, publishing most frequently in Nitric Oxide, Journal of Biological Chemistry, and Inorganic Chemistry.
Recent work continues to explore the role of nitric oxide in inflammation and cancer therapy, the stability of S-nitroso compounds in biomedical contexts, and the distribution of nitrate reductases in the human intestinal microbiota.