Advanced Tissue Imaging and Staining for Bone, Brain and Soft Tissue
This research community develops and applies high-resolution imaging techniques, including X-ray phase-contrast tomography and electron microscopy, to visualize the internal structure of bones, brains, and soft tissues in human and animal models.
The work centers on non-destructive 3D visualization of biological structures, specifically using synchrotron radiation and micro-computed tomography to image bone marrow, adipose tissue, and peripheral nerves. Recurring methods include iodine staining and virtual histology, which allow researchers to distinguish cell types and tissue compartments within intact organs. Applications span the study of bone marrow adipose tissue, breast cancer pathology, and brain development in mice. The community also utilizes finite element modeling to analyze mechanical properties of these tissues, bridging the gap between structural imaging and functional understanding.
The largest share of the community's output is found in gold research, accounting for 0.5% of all gold-related papers, with 1,017 papers in this group. Osmium research also features prominently, representing 1.7% of all osmium research with 216 papers.
The community comprises 7,556 papers, published most frequently in the Journal of Histochemistry & Cytochemistry, Brain Research, and the Journal of Comparative Neurology.
Recent work continues to focus on high-resolution multimodal imaging of airway mucus plugging in mice and 3D strain distribution in osteochondral units, alongside guides for immunoelectron microscopy sample preparation.