Hyperpolarized Xenon MRI and Gas Spectroscopy for Lung and Brain Imaging
This community develops magnetic resonance imaging techniques using hyperpolarized xenon and nitrous oxide to visualize lung ventilation, perfusion, and gas exchange, as well as cerebral blood flow in patients with respiratory and neurological conditions.
The work centers on the application of hyperpolarized 129Xe MRI and NMR spectroscopy to assess lung function in diseases such as chronic obstructive pulmonary disease, cystic fibrosis, and pulmonary fibrosis. Key methods include measuring ventilation-perfusion matching, gas exchange efficiency, and regional lung function in clinical settings. A significant portion of the research also applies these magnetic resonance and spectroscopic techniques to the brain, specifically investigating cerebral blood flow, autoregulation, and injury mechanisms following traumatic brain injury or cardiac arrest. The community bridges physics and clinical medicine, with frequent publication in anesthesia and respiratory journals, reflecting the dual focus on gas delivery and physiological assessment.
The largest share of the community's output is found in xenon research, accounting for 15.0% of all xenon research, and 2,367 papers here. This is the element with the highest paper count within this group.
The community comprises 6,450 papers, publishing most frequently in Anesthesiology, Magnetic Resonance in Medicine, and the British Journal of Anaesthesia.
Recent work continues to focus on post-resuscitation care guidelines, the pathophysiology of cerebral vascular disturbances after traumatic brain injury, and the role of small airway disease in chronic obstructive pulmonary disease, alongside reviews of peri-operative pharmacological interventions for postoperative delirium.
Papers behind this description
- Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary — American Journal of Respiratory and Critical Care Medicine, 2023 — doi:10.1164/rccm.202301-0106pp
- Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study — Biological Psychiatry, 2023 — doi:10.1016/j.biopsych.2022.08.025
- Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation — Physiological Reviews, 2021 — doi:10.1152/physrev.00022.2020
- Outcomes in High-Risk Pulmonary Embolism Patients Undergoing FlowTriever Mechanical Thrombectomy or Other Contemporary Therapies: Results From the FLAME Study — Circulation: Cardiovascular Interventions, 2023 — doi:10.1161/circinterventions.123.013406
- Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis — Intensive Care Medicine, 2021 — doi:10.1007/s00134-021-06548-2
- 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) — European Respiratory Journal, 2019 — doi:10.1183/13993003.01647-2019
- Looking beyond bronchopulmonary dysplasia: prematurity-associated lung disease and its phenotypes — The Lancet Respiratory Medicine, 2025 — doi:10.1016/s2213-2600(25)00372-800372-8)
- Cerebral Vascular Disturbances Following Traumatic Brain Injury: Pathophysiology, Diagnosis, and Therapeutic Perspectives—A Narrative Review — Life, 2025 — doi:10.3390/life15091470
- Advances in artificial intelligence applications for the management of chronic obstructive pulmonary disease — Frontiers in Medicine, 2025 — doi:10.3389/fmed.2025.1685254