Palladium- and Nickel-Catalyzed Carbonylation of Aryl and Alkyl Halides
This community develops catalytic methods to insert carbon monoxide into organic molecules, primarily using palladium and nickel catalysts to convert aryl and alkyl halides into carboxylic acids, amides, and ketones.
The work centers on the design of transition-metal catalysts that facilitate the insertion of carbon monoxide into carbon-carbon and carbon-heteroatom bonds. Recurring methods include palladium-catalyzed carbonylative coupling, aminocarbonylation, and cyclization reactions. Substrates frequently involve aryl iodides, bromides, and boronic acids, as well as alkyl halides and alkenes. The resulting products are typically carboxylic acids, amides, esters, and ketones. Recent efforts also explore the use of cobalt, iron, and copper catalysts, as well as photochemical and electrochemical activation strategies to expand the scope of these transformations beyond traditional palladium systems.
The largest share of the community's output is found in palladium research, accounting for 2.8% of all palladium research, with 2,456 papers here. Carbon research also features prominently, contributing 1,233 papers, though this represents only 0.1% of total carbon research.
The community comprises 5,872 papers, published primarily in The Journal of Organic Chemistry, Tetrahedron Letters, and Synthesis.
Recent work includes the development of asymmetric carbonylation of alkynes to axially chiral esters, cobalt-catalyzed alkene carbonylation under tandem electro-thermo-catalysis, and iron-catalyzed synthesis of tert-alkyl thioesters.