Nanotoxicology of Engineered Metal Oxides and Particulate Matter
This community investigates the biological effects of engineered nanoparticles and airborne particulate matter, focusing on mechanisms of cellular damage, oxidative stress, and human health risk assessment.
The research centers on the toxicity of metal oxide nanoparticles, particularly titanium dioxide, silica, and zinc oxide, as well as carbon black and other particulate matter. Recurring themes include the induction of oxidative stress, DNA damage, and inflammatory responses in epithelial cells and animal models such as rats and mice. Methodologies frequently involve in vitro and in vivo exposure studies, comet assays for genotoxicity, and risk assessment frameworks. The work also examines the gut microbiota and the translocation of particles from the lung to other tissues, addressing both the chemical properties of the nanomaterials and their physiological consequences in human and environmental contexts.
The largest share of the community's output is found in titanium research, accounting for 3,146 papers, which is also the element with the highest paper count within this group. Silicon and zinc research follow with 700 and 507 papers, respectively.
The community comprises 8,534 papers, publishing most frequently in Particle and Fibre Toxicology, Nanotoxicology, and the International Journal of Nanomedicine.
Recent work continues to focus on comprehensive reviews of nanomaterial toxicity mechanisms, the health implications of food additive preservatives, and the ecotoxicology of nanoparticles in aquatic organisms, alongside assessments of human health risks from food consumption and cosmetic exposure.