Chromatography and Mass Spectrometry for Bioanalytical and Environmental Analysis
This research community develops and validates analytical methods for separating, extracting, and quantifying complex mixtures of chemicals in biological fluids, food products, and environmental samples.
The work centers on coupling liquid and gas chromatography with tandem mass spectrometry to detect trace levels of target compounds. Recurring applications include the simultaneous determination of pharmaceuticals in human plasma and serum, the quantification of polycyclic aromatic hydrocarbons and other organic pollutants in water and food matrices, and the analysis of natural products. A significant portion of the research focuses on sample preparation techniques, specifically solid-phase microextraction and solid-phase extraction, often utilizing advanced sorbent materials such as graphene oxide, covalent organic frameworks, and porous carbon nanosheets to enhance sensitivity and selectivity.
Nitrogen research accounts for the largest share of this community’s output, representing 0.2% of all tracked nitrogen research, with 941 papers in this group. Sodium and Phosphorus also show a 0.2% share, with 651 and 601 papers respectively. The community comprises 17,734 papers, published predominantly in the Journal of Chromatography A, the Journal of Chromatography B: Biomedical Sciences and Applications, and Analytical Chemistry.
Recent work continues to focus on developing novel sorbent materials for microextraction, such as covalent organic frameworks and porous carbon nanosheets, to improve the detection of antifungal drugs in plasma and polychlorinated biphenyls in beverages. Other recent studies address the extraction of bio-produced chemicals from fermentation broths and the analysis of fatty acid compositions in dairy products.