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Lead compound
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Current data, viewed at
Yearly
resolution.
Personal members see monthly resolution →
Keyword
keyword
Lead compound
RIS
0.002
(Research Intensity Score)
Papers
210
Top papers
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
2020 · 3453 citations
Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design
2021 · 689 citations
A dual diffusion model enables 3D molecule generation and lead optimization based on target pockets
2024 · 149 citations
Unveiling the hidden interactome of CRBN molecular glues
2025 · 58 citations
Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors
2025 · 61 citations
Newest papers
High-throughput screening and structure-guided design of small molecules enable modulation of SAL-PAP stress signaling
2026 · 2 citations
Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression
2026 · 3 citations
A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy
2026 · 2 citations
Rosmarinic Acid Is an hCtr1 Inhibitor that Interferes with Copper Transport Activity
2026 · 2 citations
Biotransformation-guided production of quinalizarin as an antibacterial agent against Acinetobacter baumannii
2026
A sample from the 100 top papers behind Lead compound.
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