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Phospholipid-hydroperoxide glutathione peroxidase
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Phospholipid-hydroperoxide glutathione peroxidase
RIS
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(Research Intensity Score)
Papers
50
Top papers
Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis
2022 · 881 citations
GPX4 in cell death, autophagy, and disease
2023 · 574 citations
Copper-dependent autophagic degradation of GPX4 drives ferroptosis
2023 · 606 citations
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1
2020 · 601 citations
The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities
2022 · 235 citations
GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis
2019 · 1063 citations
Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review
2020 · 249 citations
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
2016 · 2312 citations
FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
2018 · 725 citations
Newest papers
Hypoxia-driven lncRNA SHIELD promotes GPX4 translation and protects against ferroptosis in hepatocellular carcinoma
2026 · 2 citations
Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity
2026 · 2 citations
Simultaneous Down-Regulation of Intracellular hTERT and GPX4 mRNA Using MnO2-Nanosheet Probes to Induce Cancer Cell Death
2026 · 1 citations
Selenoproteins: Zoom-In to Their Metal-Binding Properties in Neurodegenerative Diseases
2025 · 12 citations
CRISPR screen reveals a simultaneous targeted mechanism to reduce cancer cell selenium and increase lipid oxidation to induce ferroptosis
2025 · 9 citations
Selenium–GPX4 Axis Relieves Arachidonic Acid-Induced Sperm Damage
2025 · 5 citations
Novel role of peroxiredoxin 6 in ferroptosis: Bridging selenium transport with enzymatic functions
2025 · 6 citations
GPX4 in cell death, autophagy, and disease
2023 · 574 citations
Copper-dependent autophagic degradation of GPX4 drives ferroptosis
2023 · 606 citations
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