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Synthetic lethality
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Keyword
keyword
Synthetic lethality
RIS
0.001
(Research Intensity Score)
Papers
97
Top papers
Metabolic regulation of homologous recombination repair by MRE11 lactylation
2023 · 428 citations
Reactive Oxygen Species: A Double-Edged Sword in the Modulation of Cancer Signaling Pathway Dynamics
2025 · 59 citations
A new wave of innovations within the DNA damage response
2023 · 132 citations
BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality
2023 · 135 citations
Methylthioadenosine Phosphorylase Genomic Loss in Advanced Gastrointestinal Cancers
2024 · 35 citations
Overcoming Platinum and PARP-Inhibitor Resistance in Ovarian Cancer
2020 · 214 citations
Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts
2024 · 22 citations
Targeting oncogenic Myc as a strategy for cancer treatment
2018 · 680 citations
Chemoresistance in ovarian cancer (I)
2026 · 8 citations
Newest papers
Chemoresistance in ovarian cancer (I)
2026 · 8 citations
Restoration of chemosensitivity to drug resistant breast cancer cells through peptide activation of the anaphase promoting complex
2026 · 1 citations
Multimodal interrogation establishes the AAA+ ATPase RUVBL1 as a prognostic driver and tractable dependency in malignant pleural mesothelioma
2026
Overcoming mTOR Inhibitor Resistance: From Biological Basis to Therapeutic Strategies
2026
Genome-wide CRISPR screen identifies AMBRA1 as a potential biomarker of response to platinum-based therapies in oral squamous cell carcinomas
2026
HAMNO and CGK733 as BRCAness-driven candidates exhibit synthetic lethality with olaparib in BRCA-proficient ovarian cancer
2026
From dual inhibition to precision selectivity: the molecular rationale and clinical evolution of next-generation PARP1-selective inhibitors in solid tumors
2026
Recent Progress in Targeting Kinases Involved in the DNA Damage Response for the Treatment of Cancer
2026
Nucleotide excision repair in tumor response to DNA-damaging anticancer therapies: a comprehensive review
2026
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