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Topoisomerase
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Current data, viewed at
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Keyword
keyword
Topoisomerase
RIS
0.002
(Research Intensity Score)
Papers
216
Top papers
HERTHENA-Lung01, a Phase II Trial of Patritumab Deruxtecan (HER3-DXd) in Epidermal Growth Factor Receptor–Mutated Non–Small-Cell Lung Cancer After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Platinum-Based Chemotherapy
2023 · 238 citations
Datopotamab Deruxtecan in Advanced or Metastatic Non–Small Cell Lung Cancer With Actionable Genomic Alterations: Results From the Phase II TROPION-Lung05 Study
2025 · 115 citations
Doxorubicin-Induced Cardiotoxicity: A Comprehensive Update
2025 · 53 citations
BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality
2023 · 135 citations
A chemical perspective on the clinical use of platinum-based anticancer drugs
2022 · 126 citations
Newest papers
Oxoisoaporphine Alkaloid Piano-Stool Arene Ruthenium(II) Derivative: A cGAS-STING-Mediated Chemoimmunotherapy Inducer that Acts as a Dual Catalytic Inhibitor of Topoisomerase I/II
2026 · 3 citations
From Unmet Medical Need to Drug Candidate: A Translational Therapeutic Development Roadmap Illustrated by Dual-Payload Antibody–Drug Conjugates
2026 · 1 citations
Deruxtecan-based antibody–drug-conjugates induce senescence in HER2-positive breast cancer
2026 · 1 citations
New Insights into Binding of G-segment DNA to the Active Site of Escherichia coli Topoisomerase III
2026
DNA gyrase in live bacteria forms liquid condensates through weak multivalent bonding of excess GyrB
2026
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