Boron Neutron Capture Therapy and Particle Beam Cancer Treatment
This community develops boron-based compounds and particle beam systems for targeted cancer treatment, primarily through boron neutron capture therapy (BNCT) and proton or carbon ion therapy.
The work centers on synthesizing boron delivery agents, such as boron clusters and carboranes, to concentrate boron in tumor cells. It also involves designing compact neutron sources and accelerator systems to deliver thermal neutrons or charged particles. Researchers apply Monte Carlo simulations to model dose distribution and biological effectiveness, while clinical studies focus on treatment planning for head and neck cancers, breast cancer, and glioblastoma. The field integrates inorganic chemistry for drug design with medical physics for beam delivery and dosimetry.
The largest share of the community's output is found in boron research, accounting for 3.1% of all boron-related papers, with 4,751 papers in this group. Carbon research contributes the second-largest share at 0.2%, and helium research at 0.5%.
There are 15,827 papers in this community, published most frequently in Physics in Medicine and Biology, Applied Radiation and Isotopes, and Medical Physics.
Recent work includes the development of new boron delivery agents for neutron capture therapy, studies on the immune effects of BNCT in preclinical models, and advancements in the synthesis of boron clusters for medicinal chemistry.