Singlet Oxygen Chemistry, Photodynamic Therapy, and Proximity Labeling
This community investigates the generation, detection, and biological impact of singlet oxygen and other reactive oxygen species, while developing light-activated tools to map protein interactions and cellular structures.
The work centers on the photophysics of singlet oxygen, including its quantum yields, generation mechanisms, and quenching dynamics in aqueous and biological environments. A major strand involves the design of photosensitizers and organic compounds for photodynamic therapy, targeting cancer cells and bacterial pathogens like Staphylococcus aureus. Concurrently, researchers are advancing photocatalytic proximity labeling techniques to visualize cell surface neighbors, lipid interactomes, and chromatin states. The community also examines the enzymatic management of oxidative stress, particularly the roles of superoxide dismutase and manganese superoxide dismutase in protecting against oxidative damage.
The largest share of the community's output is found in oxygen research, accounting for 1.8% of all oxygen research, and 9,946 papers here.
The community comprises 16,316 papers, publishing most frequently in the Journal of the American Chemical Society, Photochemistry and Photobiology, and the Journal of Biological Chemistry.
Recent work focuses on applying photosensitizer proximity labeling to capture lipid and protein interactomes, as well as refining methods for detecting reactive oxygen species in photocatalytic membrane reactors and photodynamic therapy contexts.