Nanozymes and Hydrogels for Wound Repair and Biosensing
This community develops nanomaterials that mimic enzyme activity to manage oxidative stress in chronic wounds and to create sensitive platforms for detecting biological markers.
The work centers on cerium oxide and other oxide nanoparticles, often integrated into hydrogels or metal-organic frameworks, to treat diabetic foot ulcers, infected wounds, and inflammatory conditions like rheumatoid arthritis. A significant portion of the research focuses on "nanozymes" with peroxidase-like activity, designed to scavenge reactive oxygen species and restore oxidative balance in damaged tissue. Concurrently, the community engineers these materials for colorimetric and electrochemiluminescent detection, applying them to the sensitive identification of hydrogen peroxide, cancer biomarkers, and other analytes. The recurring materials include gold nanoparticles, graphene oxide, and sodium alginate, while the primary applications remain wound healing, drug delivery, and ultrasensitive biosensing.
The largest share of this community's output is found in cerium research, accounting for 5.0% of all tracked cerium papers, with 4,145 papers in this group. Oxygen research contributes the highest raw paper count, with 4,988 papers, representing 0.9% of all tracked oxygen research.
The community comprises 24,112 papers, publishing most frequently in Analytical Chemistry, Biosensors and Bioelectronics, and Chemical Engineering Journal.
Recent work continues to focus on multifunctional hydrogels for diabetic wound repair, including strategies to reprogram the metabolic microenvironment and treat antibiotic-resistant biofilms. Newer studies also explore the use of engineered nanozymes for portable, on-site detection of cancer markers and environmental contaminants, maintaining the dual focus on therapeutic delivery and sensitive analytical detection.