Fluorinated Organic Synthesis and Bioorthogonal Chemistry
This community develops methods for synthesizing fluorinated organic molecules and uses click chemistry to build biological probes and pharmaceutical candidates.
The work centers on catalytic reactions for introducing fluorine into carbon skeletons, including the synthesis of sulfonyl fluorides, gem-difluoroalkenes, and trifluoromethyl derivatives. Recurring techniques include copper- and palladium-catalyzed processes, visible-light photoredox chemistry, and azide-alkyne cycloaddition. These methods generate building blocks for drug discovery, radiopharmaceuticals for positron emission tomography, and bioorthogonal probes for imaging. The research also covers the biological evaluation of these compounds, focusing on their stability, activity, and interactions with biological systems through hydrogen bonding and molecular docking.
The largest share of the community's output is found in fluorine research, accounting for 8.9% of all fluorine research tracked, with 7,584 papers in this group. Bromine and iodine also appear frequently as co-reactants or leaving groups in these synthetic pathways.
The community comprises 28,027 papers, publishing primarily in the Journal of Fluorine Chemistry, The Journal of Organic Chemistry, and Journal of the American Chemical Society.
Recent work continues to focus on the synthesis of fluorinated pharmaceutical ingredients, radiopharmaceuticals using Fluorine-18, and the development of covalent inhibitors and antimicrobial peptides through fluorinated modifications.