Multiple Sclerosis, Neuromyelitis Optica, and Related Autoimmune Neuroinflammatory Disorders
This community focuses on the clinical management, diagnosis, and treatment of multiple sclerosis and closely related autoimmune conditions affecting the central nervous system, such as neuromyelitis optica spectrum disorder and myelin-oligodendrocyte glycoprotein antibody-associated disease.
The research is dominated by clinical studies on relapsing-remitting and progressive multiple sclerosis, with a strong emphasis on MRI imaging for lesion detection and disease activity monitoring. A significant portion of the work investigates novel therapeutic strategies, including CAR-T cell therapies and monoclonal antibodies targeting specific immune pathways. Biomarker research, particularly involving neurofilament light chain in cerebrospinal fluid and blood, is a recurring theme for assessing disease progression. The community also addresses differential diagnoses and management of optic neuritis, autoimmune encephalitis, and progressive multifocal leukoencephalopathy, often within the context of distinguishing these from primary demyelinating diseases.
Gadolinium research includes 1,816 papers from this community, representing 2.9% of all tracked Gadolinium research. Phosphorus research includes 543 papers, and Potassium research includes 186 papers.
The community comprises 11,589 papers, published primarily in Neurology, Multiple Sclerosis Journal, and Multiple Sclerosis and Related Disorders.
Recent work includes studies on anti-BCMA CAR-T therapy for progressive multiple sclerosis, the use of neurofilament biomarkers in neuroinflammation, and the efficacy of ocrelizumab in primary progressive multiple sclerosis.