Cerium Oxide Nanozymes for Wound Healing, Sensing, and Polishing
This community develops cerium oxide nanoparticles that mimic enzyme activity to manage oxidative stress in wounds, detect biological markers, and polish semiconductor surfaces.
The work centers on synthesizing cerium oxide nanoparticles, often doped or structured as metal-organic frameworks, to function as nanozymes. These materials exhibit peroxidase-like and oxidase-like activities, allowing them to scavenge reactive oxygen species and enhance wound healing, particularly in diabetic cases. The community also applies these nanoparticles in colorimetric and electrochemical sensors for detecting hydrogen peroxide and other analytes. A significant portion of the research focuses on chemical mechanical polishing, where cerium oxide particles serve as abrasives for surface finishing. Recent efforts integrate these nanozymes into hydrogels and responsive materials to create multifunctional platforms for antibacterial treatment and tissue regeneration.
The largest share of the community's output is found in cerium research, accounting for 22.4% of all cerium research, and 4,189 papers here.
The community comprises 9,410 papers, publishing most frequently in Chemical Engineering Journal, Ceramics International, and ACS Nano.
Recent work focuses on cerium-based nanozymes for portable cancer screening, the treatment of multidrug-resistant bacterial infections in diabetic wounds, and the development of responsive hydrogels for bone regeneration and periodontal defect repair.
Papers behind this description
- The wound microbiota: microbial mechanisms of impaired wound healing and infection — Nature Reviews Microbiology, 2024 — doi:10.1038/s41579-024-01035-z
- Nanozymes expanding the boundaries of biocatalysis — Nature Communications, 2025 — doi:10.1038/s41467-025-62063-8
- Designing nanozymes for in vivo applications — Nature Reviews Bioengineering, 2024 — doi:10.1038/s44222-024-00205-1
- Nanozymes: Definition, Activity, and Mechanisms — Advanced Materials, 2023 — doi:10.1002/adma.202211041
- Hyperthermia-enhanced immunoregulation hydrogel for oxygenation and ROS neutralization in diabetic foot ulcers — Cell Biomaterials, 2025 — doi:10.1016/j.celbio.2025.100020
- Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme — Nature Communications, 2023 — doi:10.1038/s41467-023-35828-2
- Microenvironment-Responsive Metal-Phenolic Nanozyme Release Platform with Antibacterial, ROS Scavenging, and Osteogenesis for Periodontitis — ACS Nano, 2023 — doi:10.1021/acsnano.3c01940
- Programmed microalgae-gel promotes chronic wound healing in diabetes — Nature Communications, 2024 — doi:10.1038/s41467-024-45101-9
- Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing — Nature Communications, 2024 — doi:10.1038/s41467-024-47696-5
- Tailored Metal–Organic Framework‐Based Nanozymes for Enhanced Enzyme‐Like Catalysis — Angewandte Chemie International Edition, 2024 — doi:10.1002/anie.202420200
- pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing — ACS Nano, 2022 — doi:10.1021/acsnano.1c11040
- Biomedical Applications of Nanozymes: An Enzymology Perspective — Angewandte Chemie International Edition, 2025 — doi:10.1002/anie.202512409
- Two-Dimensional Dissipative Paper-Based Immunoassay with Oxygen Vacancy-Enriched CeO 2 Nanozymes for Portable Cancer Screening — Analytical Chemistry, 2025 — doi:10.1021/acs.analchem.5c03445
- Cu single-atom embedded g-C3N4 nanosheets rehabilitate multidrug-resistant bacteria infected diabetic wounds via photoswitchable cascade reaction — Nature Communications, 2025 — doi:10.1038/s41467-025-64242-z
- Oxygen-vacancy engineering and junction design in CeO2 nanomaterials for photocatalysis and antibacterial action: A review — Results in Engineering, 2025 — doi:10.1016/j.rineng.2025.108076
- A Flexible Electrochemical Sensor Based on Porous Ceria Hollow Microspheres Nanozyme for Sensitive Detection of H2O2 — Biosensors, 2025 — doi:10.3390/bios15100664
- Cerium-based metal–organic framework nanozyme with high oxidase-like activity at neutral pH for discrimination and detection of antioxidants — Biosensors and Bioelectronics, 2025 — doi:10.1016/j.bios.2025.117608