Transition-Metal-Catalyzed Asymmetric Synthesis of Chiral Molecules
This community develops catalytic methods to build complex, three-dimensional molecular structures with precise handedness, providing the foundational tools for creating chiral pharmaceuticals and advanced materials.
The work centers on the development of asymmetric catalytic systems using gold, palladium, rhodium, and copper complexes, alongside chiral phosphoric acid organocatalysts. Recurring methodologies include allylic alkylation and substitution, cycloaddition reactions, and cyclization processes designed to generate enantioenriched products. Specific focus areas include the synthesis of axially chiral compounds, the formation of quaternary centers, and the control of stereoselectivity in reactions involving terminal alkynes and diazo compounds. These methods enable the stereodivergent access to non-natural amino acids and the construction of spirocyclic and helically chiral architectures.
The community is most heavily represented in research tracked for rhodium, accounting for 9.1% of all rhodium research, and palladium, representing 6.4% of that element's output. Gold research contributes 2.2% of its total volume, while the community contains 6,430 papers related to palladium and 4,622 related to gold.
The community comprises 32,681 papers, with the highest publication volumes appearing in Organic Letters, The Journal of Organic Chemistry, and the Journal of the American Chemical Society. Recent work includes the control of pyramidal nitrogen chirality via asymmetric organocatalysis, the enantioselective dearomative skeletal editing of benzofurans, and the synthesis of axially chiral phosphines through nickel-catalyzed cycloaddition.