Boron Neutron Capture Therapy and Particle Beam Cancer Treatment
This community develops boron-based compounds and particle beam delivery systems for targeted cancer treatment, specifically focusing on neutron capture therapy and proton or ion beam radiotherapy.
The work centers on the synthesis of boron delivery agents, such as carboranes and boron clusters, designed to concentrate boron within tumor cells. It also involves the engineering of compact neutron sources and the application of Monte Carlo simulations to model dose distribution and biological effectiveness. These methods are applied to treat head and neck cancers, breast cancer, and other solid tumors, with a focus on minimizing damage to surrounding healthy tissue through precise beam control and targeted boron uptake.
The largest share of the community's output is found in boron research, accounting for 3.0% of all tracked boron papers, with 4,615 papers in this group. This is the element with the highest paper count within the community.
The community comprises 15,281 papers, primarily published in Applied Radiation and Isotopes, Physics in Medicine and Biology, and Medical Physics.
Recent work focuses on the development of novel boron cluster agents for neutron capture therapy and the investigation of immune responses induced by this treatment in preclinical models.