Heavy Metal Toxicology and Human Health Risk Assessment
This community investigates the biological effects of toxic metal exposure on human and animal health, focusing on mechanisms of injury and methods for assessing population-level risk.
The research centers on cadmium, lead, and manganese, examining how these elements induce oxidative stress and cellular damage. Common methodologies include animal studies using rat models, blood analysis for biomarkers, and risk assessment frameworks to quantify health hazards. The work spans acute toxicity mechanisms, such as signaling pathway disruption, to chronic exposure scenarios involving drinking water and food sources. Recurring themes include the protective effects of antioxidants against metal-induced damage and the correlation between metal levels in biological fluids and disease outcomes.
Cadmium research constitutes the largest share of this community's output, representing 17.3% of all cadmium research tracked, with 7,158 papers. Manganese and lead follow, accounting for 6.6% and 6.4% of their respective element research, with 2,373 and 1,797 papers in this group.
The community comprises 18,352 papers, publishing primarily in Biological Trace Element Research, Ecotoxicology and Environmental Safety, and Environmental Research.
Recent work continues to focus on the mechanisms of lead toxicity in living organisms and the safety analysis of heavy metals in food products like milk and dairy.
Papers behind this description
- Heavy metals: toxicity and human health effects — Archives of Toxicology, 2024 — doi:10.1007/s00204-024-03903-2
- Essential metals in health and disease — Chemico-Biological Interactions, 2022 — doi:10.1016/j.cbi.2022.110173
- Heavy Metal Exposure and Cardiovascular Disease — Circulation Research, 2024 — doi:10.1161/circresaha.123.323617
- Cadmium Toxicity and Health Effects—A Brief Summary — Molecules, 2023 — doi:10.3390/molecules28186620
- Assessing Heavy Metal Contamination in Food: Implications for Human Health and Environmental Safety — Toxics, 2025 — doi:10.3390/toxics13050333
- Cadmium Exposure: Mechanisms and Pathways of Toxicity and Implications for Human Health — Toxics, 2024 — doi:10.3390/toxics12060388
- Effects of heavy metals on fish physiology – A review — Chemosphere, 2022 — doi:10.1016/j.chemosphere.2022.134519
- Biological Effects of Human Exposure to Environmental Cadmium — Biomolecules, 2022 — doi:10.3390/biom13010036
- Association between manganese exposure in heavy metals mixtures and the prevalence of sarcopenia in US adults from NHANES 2011–2018 — Journal of Hazardous Materials, 2024 — doi:10.1016/j.jhazmat.2023.133005
- Global health burden and cost of lead exposure in children and adults: a health impact and economic modelling analysis — The Lancet Planetary Health, 2023 — doi:10.1016/s2542-5196(23)00166-300166-3)
- The Mechanisms of Lead Toxicity in Living Organisms — Journal of Xenobiotics, 2025 — doi:10.3390/jox15050146
- Heavy Metals in Milk and Dairy Products: Safety and Analysis — Pollutants, 2025 — doi:10.3390/pollutants5030029
- From origin to oversight: properties, impacts and management of heavy metals — Discover Applied Sciences, 2025 — doi:10.1007/s42452-025-07880-8
- Dual-pathway mechanism of vanadium-induced hepatotoxicity in ducks: Synergistic crosstalk between glucose homeostasis disruption and NADH/FSP1/COQ10 axis-driven ferroptosis — International Journal of Biological Sciences, 2025 — doi:10.7150/ijbs.123482
- Heavy Metals Like Aluminum, Arsenic, Cadmium, Chromium, Copper, Iron, Lead, Manganese, Mercury, Nickel, and Zinc Polluting the Drinking Water: Their Individual Health Hazards — International Journal of Molecular Sciences, 2025 — doi:10.3390/ijms262311656
- Heavy metals and human reproductive toxicity: Mechanisms, pregnancy outcomes, and mitigation strategies — Reproductive Toxicology, 2025 — doi:10.1016/j.reprotox.2025.109104