Nanomedicine for Phototherapy, Wound Repair, and Cancer Immunomodulation
This research community develops nanomaterials and biomaterials to treat cancer and chronic wounds, primarily by using light-activated therapies and reactive oxygen species to target tumors and regulate oxidative stress in healing tissues.
The work centers on the synthesis of nanoparticles, nanozymes, and hydrogels designed for photodynamic and photothermal therapy, as well as drug delivery systems. Recurring materials include cerium oxide, gold, and metal-organic frameworks, which are engineered to generate singlet oxygen or modulate the tumor microenvironment. A significant portion of the research addresses diabetic wound healing and antimicrobial resistance, utilizing reactive oxygen species to combat infection and promote tissue repair. The literature frequently describes synergistic combinations of these physical and chemical treatments to enhance efficacy against breast cancer, colorectal cancer, and other malignancies, while also exploring colorimetric detection methods for diagnostic purposes.
The community’s output is most heavily concentrated in oxygen research, representing 2.8% of all tracked oxygen studies, followed by cerium (4.4%) and gold (1.1%). Oxygen also contributes the highest absolute number of papers to this group, with 14,301 entries, while cerium contributes 3,326 papers.
The community comprises 49,614 papers, with the highest publication volumes in Photodiagnosis and Photodynamic Therapy, Chemical Engineering Journal, and ACS Nano.
Recent work focuses on multifunctional hydrogels for diabetic foot ulcers, nanozyme-based platforms for reprogramming oxidative stress, and strategies to convert "cold" tumors into "hot" ones to enhance immunotherapy. Newer studies also explore metal-polyphenol nanocomposites for biofilm infections and machine learning-assisted design of photosensitizers for nasopharyngeal carcinoma.