Reactive Oxygen Species Signaling, Oxidative Stress and Mitochondrial Function in Disease
This community investigates how reactive oxygen species (ROS) and nitric oxide regulate cellular signaling, mitochondrial health, and cell death, primarily to understand and treat conditions like cancer, diabetes, and neurodegenerative disorders.
The research focuses heavily on the mechanisms of oxidative stress and antioxidant activity, with frequent examination of mitochondrial dysfunction and specific signaling pathways. Recurring applications include targeted therapies for breast, lung, and colorectal cancers, as well as studies on gut microbiota and inflammatory conditions like ulcerative colitis. Common experimental models involve mouse studies using dextran sulfate or sodium butyrate, alongside the development of fluorescent probes to detect oxygen species. The work also explores the role of nitric oxide in vascular and neurological contexts, linking these molecular processes to broader physiological outcomes in human patients.
The largest share of this community's output is found in oxygen research, accounting for 19.0% of all oxygen-related papers, with 20,469 papers in this group. Bromine research also shows a significant presence, representing 3.0% of that element's tracked literature.
There are 89,026 papers in this community, with the highest volume published in the Journal of Biological Chemistry, Nitric Oxide, and Free Radical Biology and Medicine.
Recent work continues to examine the interplay between oxidative stress, inflammation, and mitochondrial dysfunction in metabolic and neurodegenerative diseases, with specific attention to therapeutic strategies targeting ROS homeostasis and the gut-brain axis.