Electrolyte Balance and Mineral Metabolism in Chronic Kidney and Cardiovascular Disease
This community investigates the clinical management of essential minerals—specifically magnesium, calcium, sodium, potassium, and phosphorus—within patients suffering from chronic kidney disease, heart failure, and diabetes. The work focuses on how dietary intake, serum levels, and pharmacological interventions like zirconium cyclosilicate affect patient outcomes, including blood pressure, mortality, and bone health.
The research is dominated by randomized controlled trials and systematic meta-analyses examining the association between serum electrolyte levels and disease progression. Key interventions include magnesium supplementation, sodium chloride restriction, and the use of binders such as zirconium cyclosilicate to manage hyperphosphatemia. The literature frequently addresses the complex interplay between calcium-phosphorus homeostasis and mineral and bone disorders in hemodialysis patients, alongside the cardiovascular risks associated with sodium-potassium imbalance in hypertensive and diabetic populations.
The largest share of the community's output is found in magnesium research, accounting for 7.8% of all magnesium research, and 2,720 papers here. Calcium and potassium follow, representing 5.0% and 6.5% of their respective element research, with 1,758 and 1,615 papers in this group.
The community comprises 11,753 papers, publishing most frequently in Nutrients, Food Chemistry, and Magnesium Research. Recent work includes clinical guidelines for osteoporosis and hypoparathyroidism, as well as studies on the bioavailability of calcium peptide chelates and the public health burden of magnesium deficiency.
Papers behind this description
- 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines — Hypertension, 2025 — doi:10.1161/hyp.0000000000000249
- Chronic kidney disease–mineral and bone disorder: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference — Kidney International, 2025 — doi:10.1016/j.kint.2024.11.013
- The burden of diseases, injuries, and risk factors by state in the USA, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 — The Lancet, 2024 — doi:10.1016/s0140-6736(24)01446-601446-6)
- KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary — Kidney International, 2025 — doi:10.1016/j.kint.2024.07.010
- KDIGO 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) — Kidney International, 2025 — doi:10.1016/j.kint.2024.07.009
- British Dietetic Association Guidelines for the Dietary Management of Chronic Constipation in Adults — Journal of Human Nutrition and Dietetics, 2025 — doi:10.1111/jhn.70133
- ASN Kidney Health Guidance on Potassium and Phosphorus Food Additives — Journal of the American Society of Nephrology, 2025 — doi:10.1681/asn.0000000873