Redox Signaling, Ion Channel Dynamics, and Targeted Cancer Therapy
This research community investigates how reactive oxygen species, calcium and potassium ion signaling, and mitochondrial function regulate cell survival and death in diseases such as cancer, heart failure, and neurodegeneration.
The work centers on the molecular mechanisms of oxidative stress and ferroptosis, with a heavy focus on targeted therapies for breast, lung, and colorectal cancers. Recurring themes include the role of iron homeostasis in cell death, the modulation of potassium and calcium channels in cardiac and neuronal signaling, and the development of fluorescent probes to track reactive oxygen species in real time. The community also examines how mitochondrial dysfunction drives pathology in Alzheimer’s disease and type 2 diabetes, linking these processes to broader signaling pathways like AMPK/SIRT1.
The largest share of the community's output is found in oxygen research, accounting for 17.5% of all oxygen-related papers, followed by calcium at 8.9% and potassium at 8.0%. Oxygen also contributes the highest raw paper count within this group, with 5,537 papers.
The community comprises 42,175 papers, publishing most frequently in Cell Calcium, Signal Transduction and Targeted Therapy, and the Journal of Biological Chemistry.
Recent work continues to focus on the interplay between oxidative stress and inflammation, with new studies exploring the conversion of "cold" tumors to "hot" ones for immunotherapy and the role of mitochondrial membrane potential in compartmentalized signaling.
Papers behind this description
- Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects — Signal Transduction and Targeted Therapy, 2024 — doi:10.1038/s41392-024-01969-z
- Cold and hot tumors: from molecular mechanisms to targeted therapy — Signal Transduction and Targeted Therapy, 2024 — doi:10.1038/s41392-024-01979-x
- Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications — Acta Pharmaceutica Sinica B, 2024 — doi:10.1016/j.apsb.2024.10.004
- Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies — Signal Transduction and Targeted Therapy, 2024 — doi:10.1038/s41392-024-01769-5
- Adeno-associated virus as a delivery vector for gene therapy of human diseases — Signal Transduction and Targeted Therapy, 2024 — doi:10.1038/s41392-024-01780-w
- Hyperuricemia and its related diseases: mechanisms and advances in therapy — Signal Transduction and Targeted Therapy, 2024 — doi:10.1038/s41392-024-01916-y
- Tumor biomarkers for diagnosis, prognosis and targeted therapy — Signal Transduction and Targeted Therapy, 2024 — doi:10.1038/s41392-024-01823-2
- AMPK/SIRT1/PGC‐1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy — CNS Neuroscience & Therapeutics, 2025 — doi:10.1111/cns.70657
- Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential — Signal Transduction and Targeted Therapy, 2025 — doi:10.1038/s41392-025-02326-4
- Exploring the Interplay of Antioxidants, Inflammation, and Oxidative Stress: Mechanisms, Therapeutic Potential, and Clinical Implications — Diseases, 2025 — doi:10.3390/diseases13090309
- Mitochondrial membrane potential and compartmentalized signaling: Calcium, ROS, and beyond — Redox Biology, 2025 — doi:10.1016/j.redox.2025.103859
- Cell-type-directed network-correcting combination therapy for Alzheimer’s disease — Cell, 2025 — doi:10.1016/j.cell.2025.06.035
- Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression — Archives of Toxicology, 2025 — doi:10.1007/s00204-025-04146-5