Transition-Metal-Catalyzed Cross-Coupling and Asymmetric Synthesis
This community focuses on the development of catalytic methods to form carbon-carbon and carbon-heteroatom bonds, primarily using transition metals like palladium, copper, and nickel, to enable the efficient and selective construction of complex organic molecules.
The work centers on cross-coupling reactions, including Suzuki-Miyaura and related variants, which connect aryl halides with various coupling partners. A significant portion of the research addresses enantioselective and asymmetric synthesis, utilizing chiral ligands and catalysts to produce optically active derivatives. Key methodologies involve the activation of inert bonds, such as C-H bonds, and the use of hypervalent iodine reagents. The community also explores the integration of visible light photocatalysis with transition metal catalysis to drive radical transformations. These methods are applied to the total synthesis of natural products and the creation of drug-like molecules, with a strong emphasis on developing efficient, one-pot synthetic routes that minimize waste and maximize yield.
The largest share of the community's output is found in palladium research, accounting for 45.3% of all palladium research tracked, and 24,708 papers here. Rhodium research also shows a high relative share at 28.2%, while iodine, nickel, and ruthenium contribute smaller but significant portions of their respective elemental research to this group.
The community comprises 126,017 papers, publishing most frequently in Tetrahedron Letters, The Journal of Organic Chemistry, and the Journal of the American Chemical Society.
Recent work includes the development of iron photocatalysis mechanisms, copper-catalyzed asymmetric C-H sulfilimination, and the divergent synthesis of bioisosteres via photoinduced palladium catalysis.